Comparative study of encapsulated cannabidiol ternary solid dispersions prepared by different techniques: The application of a novel technique jet milling

Hang Li; Tian-Xiao Yang; Qing-Sheng Zhao; Shou-Bu Hou; Rong-Rong Tian; Bing Zhao

doi:10.1016/j.foodres.2023.112783

Comparative study of encapsulated cannabidiol ternary solid dispersions prepared by different techniques: The application of a novel technique jet milling

Food Res Int. 2023 Jun:168:112783. doi: 10.1016/j.foodres.2023.112783. Epub 2023 Apr 12.

Authors

Hang Li¹, Tian-Xiao Yang², Qing-Sheng Zhao³, Shou-Bu Hou⁴, Rong-Rong Tian⁵, Bing Zhao⁶

Affiliations

¹ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: lihang18@mails.ucas.edu.cn.
² Department of Biomedicine, Beijing City University, Beijing 100094, China.
³ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: qszhao@ipe.ac.cn.
⁴ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: houshoubu20@mails.ucas.edu.cn.
⁵ Department of Biomedicine, Beijing City University, Beijing 100094, China. Electronic address: rongx2tian@bcu.edu.cn.
⁶ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: bzhao@ipe.ac.cn.

PMID: 37120229
DOI: 10.1016/j.foodres.2023.112783

Abstract

Jet milling is a common technique in ultrafine powder preparation field. It has never been used to design delivery systems. Cannabidiol (CBD) is an important cannabinoid of hemp but poor aqueous solubility limited its applications. In this study, solid dispersion (SD) technique was combined with cyclodextrin complexation technique, and jet milling was used for the first time to prepare SDs for improving CBD solubility. Different characterizations demonstrated that the dispersion effect and complexation structure of CBD SD3 prepared by jet milling were comparable to that of CBD SD2 prepared by spray drying (a common solution-based method), and were better than that of CBD SD1 prepared by cogrinding. The water solubility of CBD was increased to 20.902 μg/mL (909-fold) in CBD SD3. Besides, the antioxidant activity and cytotoxicity to tumor cells of CBD were enhanced by dispersion. This work indicated that jet milling, as a new technique with low cost and excellent applicability, could be further developed for the delivery of food functional factors or bioactive molecules.

Keywords: Aqueous solubility; Cannabidiol; Cyclodextrin; Delivery; Jet milling; Solid dispersion.

MeSH terms

Cannabidiol* / chemistry
Powders / chemistry
Solubility
Water / chemistry

Substances

Cannabidiol
Water
Powders