New insights into the role of long non-coding RNAs in osteoporosis

Weifei Zhang; Yuheng Liu; Yuanrui Luo; Xiang Shu; Congmin Pu; Bin Zhang; Pin Feng; Ao Xiong; Qingquan Kong

doi:10.1016/j.ejphar.2023.175753

New insights into the role of long non-coding RNAs in osteoporosis

Eur J Pharmacol. 2023 Jul 5:950:175753. doi: 10.1016/j.ejphar.2023.175753. Epub 2023 Apr 28.

Authors

Weifei Zhang¹, Yuheng Liu¹, Yuanrui Luo¹, Xiang Shu², Congmin Pu², Bin Zhang³, Pin Feng³, Ao Xiong⁴, Qingquan Kong⁵

Affiliations

¹ Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
² Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Sichuan University, Chengdu, 610041, China.
³ Department of Orthopedics, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, China.
⁴ Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, China. Electronic address: xiongao@189.cn.
⁵ Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; Department of Orthopedics, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: kqqspine@126.com.

PMID: 37119958
DOI: 10.1016/j.ejphar.2023.175753

Abstract

Osteoporosis is a common disease in elderly individuals, and osteoporosis can easily lead to bone and hip fractures that seriously endanger the health of elderly individuals. At present, the treatment of osteoporosis is mainly anti-osteoporosis drugs, but there are side effects associated with anti-osteoporosis drugs. Therefore, it is very important to develop early diagnostic indicators and new therapeutic drugs for the prevention and treatment of osteoporosis. Long noncoding RNAs (lncRNAs), noncoding RNAs longer than 200 nucleotides, can be used as diagnostic markers for osteoporosis, and lncRNAs play an important role in the progression of osteoporosis. Many studies have shown that lncRNAs can be the target of osteoporosis. Therefore, herein, the role of lncRNAs in osteoporosis is summarized, aiming to provide some information for the prevention and treatment of osteoporosis.

Publication types

Review

MeSH terms

Aged
Bone and Bones
Humans
Osteoporosis* / drug therapy
Osteoporosis* / genetics
RNA, Long Noncoding* / genetics
RNA, Untranslated

Substances

RNA, Long Noncoding
RNA, Untranslated