Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species

Shujie Chen; Luyi Chen; Yadong Qi; Jilei Xu; Qiwei Ge; Yuedan Fan; Du Chen; Yawen Zhang; Lan Wang; Tongyao Hou; Xiaohang Yang; Yongmei Xi; Jianmin Si; Lijun Kang; Liangjing Wang

doi:10.1038/s43587-021-00129-0

Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species

Nat Aging. 2021 Nov;1(11):991-1001. doi: 10.1038/s43587-021-00129-0. Epub 2021 Nov 16.

Authors

Shujie Chen^#^{1

2}, Luyi Chen^#^{1

2}, Yadong Qi^#^{1

2}, Jilei Xu^{1

2}, Qiwei Ge^{2

3}, Yuedan Fan^{4

5}, Du Chen^{4

5}, Yawen Zhang^{1

2}, Lan Wang^{1

2}, Tongyao Hou^{1

2}, Xiaohang Yang⁶, Yongmei Xi⁶, Jianmin Si^{7

8}, Lijun Kang^{9

10}, Liangjing Wang^{11

12}

Affiliations

¹ Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China.
² Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Zhejiang, China.
³ Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
⁴ Department of Neurobiology and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
⁵ NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Zhejiang, China.
⁶ Institute of Genetics and Department of Genetics, Division of Human Reproduction and Developmental Genetics of the Women's Hospital, Zhejiang University, Zhejiang, China.
⁷ Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China. sijm@zju.edu.cn.
⁸ Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Zhejiang, China. sijm@zju.edu.cn.
⁹ Department of Neurobiology and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China. kanglijun@zju.edu.cn.
¹⁰ NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Zhejiang, China. kanglijun@zju.edu.cn.
¹¹ Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Zhejiang, China. wangljzju@zju.edu.cn.
¹² Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China. wangljzju@zju.edu.cn.

^# Contributed equally.

PMID: 37118342
DOI: 10.1038/s43587-021-00129-0

Abstract

To identify candidate bacteria associated with aging, we performed fecal microbiota sequencing in young, middle-aged and older adults, and found lower Bifidobacterium adolescentis abundance in older individuals aged ≥60 years. Dietary supplementation of B. adolescentis improved osteoporosis and neurodegeneration in a mouse model of premature aging (Terc^-/-) and increased healthspan and lifespan in Drosophila melanogaster and Caenorhabditis elegans. B. adolescentis supplementation increased the activity of the catalase (CAT) enzyme in skeletal muscle and brain tissue from Terc^-/- mice, and suppressed cellular senescence in mouse embryonic fibroblasts. Transgenic deletion of catalase (ctl-2) in C. elegans abolished the effects of B. adolescentis on the lifespan and healthspan. B. adolescentis feeding also led to changes in oxidative stress-associated metabolites in Terc^-/- mouse feces. These results suggest a role for B. adolescentis in improving the healthspan and lifespan through the regulation of CAT activity and host metabolism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bifidobacterium adolescentis*
Caenorhabditis elegans / genetics
Catalase
Drosophila melanogaster
Fibroblasts
Longevity
Mice

Substances

Catalase