Gut mitochondrial defects drive neurodegeneration

Ricardo Aparicio; Edward T Schmid; David W Walker

doi:10.1038/s43587-022-00206-y

Gut mitochondrial defects drive neurodegeneration

Nat Aging. 2022 Apr;2(4):277-279. doi: 10.1038/s43587-022-00206-y.

Authors

Ricardo Aparicio¹, Edward T Schmid², David W Walker^{3

4}

Affiliations

¹ Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA. richyac@ucla.edu.
² Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
³ Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA. davidwalker@ucla.edu.
⁴ Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA. davidwalker@ucla.edu.

Abstract

Neurodegenerative diseases, including Parkinson’s disease, are linked to the accumulation of defective mitochondria in the brain and to microbial dysbiosis in the gut. However, the interplay between these factors is incompletely understood. Fedele et al. reveal how gut mitochondrial dysfunction activates intestinal inflammation to drive neurodegeneration in a Parkinson’s disease model.

Gut mitochondrial defects drive neurodegeneration

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