LncRNAs and related molecular basis in malignant pleural mesothelioma: Challenges and potential

Xiaoling Xu; Huihui Li; Mingying Xie; Zichao Zhou; Ding Wang; Weimin Mao

doi:10.1016/j.critrevonc.2023.104012

LncRNAs and related molecular basis in malignant pleural mesothelioma: Challenges and potential

Crit Rev Oncol Hematol. 2023 Jun:186:104012. doi: 10.1016/j.critrevonc.2023.104012. Epub 2023 Apr 26.

Authors

Xiaoling Xu¹, Huihui Li², Mingying Xie¹, Zichao Zhou¹, Ding Wang³, Weimin Mao⁴

Affiliations

¹ Key Laboratory on Diagnosis and Treatment Technology on Thoracic Cancer, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
² The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
³ Key Laboratory on Diagnosis and Treatment Technology on Thoracic Cancer, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
⁴ Key Laboratory on Diagnosis and Treatment Technology on Thoracic Cancer, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, China; Department of Thoracic Surgery, Zhejiang Cancer Hospital (Zhejiang Cancer Research Institute), Hangzhou, Zhejiang Province, China. Electronic address: maowm1318@163.com.

PMID: 37116816
DOI: 10.1016/j.critrevonc.2023.104012

Abstract

Malignant pleural mesothelioma (MPM) is a rare but invasive cancer, which mainly arises from mesothelial tissues of pleura, peritoneum and pericardium. Despite significant advances in treatments, the prognosis of MPM patients remains poor, and the 5-year survival rate is less than 10%. Therefore, it is urgent to explore novel therapeutic targets for the treatment of MPM. Growing evidence has indicated that long non-coding RNAs (lncRNAs) potentially could be promising therapeutic targets for numerous cancers. In this regard, lncRNAs might also potentially therapeutic targets for MPM. Recent advances have been made to investigate the molecular basis of MPM. This review first provides a comprehensive overview of roles of lncRNAs in MPM and then discusses the relationship between molecular basis of MPM and MPM-related lncRNAs to implement them as promising therapeutic targets for MPM.

Keywords: Long non-coding RNA; Malignant pleural mesothelioma; Therapeutic target.

Publication types

Review

MeSH terms

Humans
Lung Neoplasms* / pathology
Mesothelioma* / genetics
Mesothelioma, Malignant*
Pleural Neoplasms* / genetics
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding