Endocrinology

Abstract

Introduction: Metabolic syndrome (Syndrome X, insulin resistance syndrome) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease and diabetes mellitus. Serum uric acid and end product of purine metabolism, has been shown to be associated with an increased risk of hypertension, cardiovascular disorder and chronic kidney disease. Excess of intra abdominal or visceral adipose and not the amount of subcutaneous abdominal fat which is the key correlate of the metabolic abnormalities observed in overweight/obese patients. It is well documented that high level of insulin are associated with elevated "connecting peptide"(c-peptide) levels as both are produced in equimolar Amounts since metabolic syndrome is a well established major risk factor preceding the onset of type 2 diabetes mellitus, pre and post prandial c peptide and itís correlation with serum uric acid further strengthens this understanding and may help take preventive measures to delay/reverse the onset of type 2 diabetes mellitus.

Materials: This is a cross sectional study conducted on 60 patients with metabolic syndrome satisfying inclusion and exclusion criteria admitted in hospitals attached to Bangalore Medical College & Research Institute. All necessary investigations were done. The patients with other co-morbid condition that could affect nutritional status (diabetes mellitus, sepis, congestive heart failure, cancer) and pregnant females were excluded. Anthropometric measures, biochemical parameters were used for correlation with fasting c-peptide and post prandial c-peptide with serum uric acid in metabolic syndrome.

Result: Patients with metabolic syndrome We can observe that the Blood urea level showed positive correlation with uric acid level (p value 0.276), uric acid showed positive correlation with fasting c-peptide (p value 0.001) and post prandial c-peptide with (p value < 0.023), very low density lipoprotein showed positive correlation with post prandial c-peptide (p value < 0.022), very low density lipoprotein showed positive correlation with uric acid (p value< 0.002) triglyceride showed postive correlation with uric acid (p value < 0.001,) body mass index showed positive correlation with post prandial c peptide (p value < 0.002), body mass index showed positive correlation with uric acid (p value < 0.006).

Conclusion: Patients diagnosed as Metabolic syndrome after clinical, biochemical and anthropometric findings should be investigated for c-peptide in them which can be used as additional diagnosis factor in metabolic syndrome post prandial cpeptide being a better investigation when compared to fasting c-peptide. References Iliesiu A, Campeanu A, Dusceac D. Serum uric acid and cardiovascular disease. Maedica (Bucur) 2021;5(3):186-192. Abdullah A, Hasan H, Raigangar V, et al. C-Peptide versus insulin: relationships with risk biomarkers of cardiovascular disease in metabolic syndrome in young arab females. Int J Endocrinol 2012;2012:420792.