Management of amlodipine-induced ankle oedema

Ugeskr Laeger. 2023 Apr 17;185(16):V07220460.
[Article in Danish]

Abstract

Pedal oedema is a well-known adverse effect of amlodipine, but significantly less frequent if only half of the maximum recommended dosage is used. Diuretics are ineffective. To cause as few side effects as possible, options for managing are prioritised in this review: Reduce dosage, switch to lercanidipine/lacidipine, switch to another group, add/increase dosage of an ACE-inhibitor/angiotensin II-receptor blocker, administer at night, or switch to verapamil/diltiazem. Non-pharmacologic actions or observation may be considered when the oedemas are mild and not bothersome.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Amlodipine / adverse effects
  • Ankle
  • Calcium Channel Blockers / adverse effects
  • Drug-Related Side Effects and Adverse Reactions*
  • Edema / drug therapy
  • Humans
  • Hypertension* / drug therapy

Substances

  • Amlodipine
  • Calcium Channel Blockers