Black and Yellow Soybean Consumption Prevents High-Fat Diet-Induced Obesity by Regulating Lipid Metabolism in C57BL/6 Mice

Eun Woo Jeong; Sanjeev Kumar Dhungana; Yun Sun Yang; Youjin Baek; Jeong-Hyun Seo; Beom-Kyu Kang; Chan-Sik Jung; Sang-Ik Han; Hyeon Gyu Lee

doi:10.1155/2023/6139667

Black and Yellow Soybean Consumption Prevents High-Fat Diet-Induced Obesity by Regulating Lipid Metabolism in C57BL/6 Mice

Evid Based Complement Alternat Med. 2023 Apr 18:2023:6139667. doi: 10.1155/2023/6139667. eCollection 2023.

Authors

Eun Woo Jeong¹, Sanjeev Kumar Dhungana², Yun Sun Yang¹, Youjin Baek¹, Jeong-Hyun Seo², Beom-Kyu Kang², Chan-Sik Jung², Sang-Ik Han², Hyeon Gyu Lee¹

Affiliations

¹ Department of Food and Nutrition, Hanyang University, Seoul 04763, Republic of Korea.
² Department of Southern Area Crop Science, National Institute of Crop Science, Rural Development Administration, Miryang 50424, Republic of Korea.

Abstract

To evaluate the antiobesity effects of yellow and black soybean, C57BL/6 mice were provided with a normal diet, high-fat diet, HFD-containing yellow soybean powder (YS), and black soybean powder (BS) for six weeks. Compared with the HFD group, both YS and BS decreased body weight by 30.1% and 37.2% and fat in tissue by 33.3% and 55.8%, respectively. Simultaneously, both soybeans significantly reduced the serum triglyceride and total cholesterol levels and regulated the lipogenic mRNA expressions of Pparγ, Acc, and Fas genes in the liver, supporting reduced body adiposity. Furthermore, BS significantly increased Pgc-1α and Ucp1 mRNA expression levels in epididymal adipose tissue, indicating thermogenesis is the key mechanism of BS. Taken together, our findings suggest that both soybeans prevent high-fat diet-induced obesity in mice by regulating lipid metabolism, and BS, in particular, has a greater antiobesity potential than YS.