Toll-like receptors in cardiac hypertrophy

Yanan Zhang; Jimin Wu; Erdan Dong; Zhanli Wang; Han Xiao

doi:10.3389/fcvm.2023.1143583

Toll-like receptors in cardiac hypertrophy

Front Cardiovasc Med. 2023 Apr 11:10:1143583. doi: 10.3389/fcvm.2023.1143583. eCollection 2023.

Authors

Yanan Zhang^{1

2

3

4

5

6

7}, Jimin Wu^{2

3

4

5

6}, Erdan Dong^{2

3

4

5

6}, Zhanli Wang^{1

7}, Han Xiao^{2

3

4

5

6}

Affiliations

¹ Inner Mongolia Key Laboratory of Disease-Related Biomarkers, The Second Affiliated Hospital, Baotou Medical College, Baotou, China.
² Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
³ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University Third Hospital, Beijing, China.
⁴ Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
⁵ Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China.
⁶ Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China.
⁷ Department of Clinical Laboratory, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Abstract

Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that can identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). TLRs play an important role in the innate immune response, leading to acute and chronic inflammation. Cardiac hypertrophy, an important cardiac remodeling phenotype during cardiovascular disease, contributes to the development of heart failure. In previous decades, many studies have reported that TLR-mediated inflammation was involved in the induction of myocardium hypertrophic remodeling, suggesting that targeting TLR signaling might be an effective strategy against pathological cardiac hypertrophy. Thus, it is necessary to study the mechanisms underlying TLR functions in cardiac hypertrophy. In this review, we summarized key findings of TLR signaling in cardiac hypertrophy.

Keywords: cardiac hypertrophy; inflammation; innate immune; signaling pathway; toll-like receptor.

Publication types

Review

Grants and funding

This study was supported by the National Natural Science Foundation of China (82030072 to HX, 82170296 to ZW). CAMS Innovation Fund for Medical Sciences (2021-I2M-5–003 to ED) and the Key Clinical Projects of Peking University Third Hospital (BYSYZD2019022 to HX).