Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Run Meng; Huimin Zhu; Peiying Deng; Minghui Li; Qingzhi Ji; Hao He; Liang Jin; Bochu Wang

doi:10.3389/fbioe.2023.1137145

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Front Bioeng Biotechnol. 2023 Apr 11:11:1137145. doi: 10.3389/fbioe.2023.1137145. eCollection 2023.

Authors

Run Meng¹, Huimin Zhu², Peiying Deng¹, Minghui Li¹, Qingzhi Ji³, Hao He¹, Liang Jin¹, Bochu Wang¹

Affiliations

¹ Key Laboratory of Biorheological Science and Technology, Department of Education, College of Bioengineering, Chongqing University, Chongqing, China.
² Sheyang County Comprehensive Inspection and Testing Center, Yancheng, China.
³ School of Pharmacy, Yancheng Teachers' University, Yancheng, China.

Abstract

Albumin is derived from blood plasma and is the most abundant protein in blood plasma, which has good mechanical properties, biocompatibility and degradability, so albumin is an ideal biomaterial for biomedical applications, and drug-carriers based on albumin can better reduce the cytotoxicity of drug. Currently, there are numerous reviews summarizing the research progress on drug-loaded albumin molecules or nanoparticles. In comparison, the study of albumin-based hydrogels is a relatively small area of research, and few articles have systematically summarized the research progress of albumin-based hydrogels, especially for drug delivery and tissue engineering. Thus, this review summarizes the functional features and preparation methods of albumin-based hydrogels, different types of albumin-based hydrogels and their applications in antitumor drugs, tissue regeneration engineering, etc. Also, potential directions for future research on albumin-based hydrogels are discussed.

Keywords: albumin; cancer therapy; drug delivery; hydrogels; preparation methods; tissue engineering.

Publication types

Review

Grants and funding

This research was funded by the National Natural Science Foundation of China (No. 11972099), Chongqing Special Key Project for Technological Innovation and Application Development (CSTB2022TIAD-KPX0018), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No. 21KJB350014) and the Joint Project of Industry-University-Research of Jiangsu Province (No. BY2021476).