Successful Treatment of Respiratory Failure in a Patient with Prader-Willi Syndrome with Noninvasive Ventilation with AVAPS

Nauras Hwig; Montserrat Diaz-Abad; Victor T Peng; Jennifer Y So; Anayansi Lasso-Pirot

doi:10.1155/2023/9925144

Successful Treatment of Respiratory Failure in a Patient with Prader-Willi Syndrome with Noninvasive Ventilation with AVAPS

Case Rep Med. 2023 Apr 18:2023:9925144. doi: 10.1155/2023/9925144. eCollection 2023.

Authors

Nauras Hwig¹, Montserrat Diaz-Abad², Victor T Peng¹, Jennifer Y So², Anayansi Lasso-Pirot³

Affiliations

¹ Sleep Disorders Center, University of Maryland Medical Center, Baltimore, Maryland, USA.
² Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
³ Department of Pediatrics, Division of Pediatric Pulmonology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

Prader-Willi syndrome (PWS) is the most prevalent syndromic form of obesity, which starts during early childhood in the setting of hyperphagia. Due to the development of obesity, there is a high prevalence of obstructive sleep apnea (OSA) among these patients. This case report presents a patient with PWS with morbid obesity, severe OSA, and obesity hypoventilation syndrome admitted to the hospital for hypoxemic and hypercapnic respiratory failure. Noninvasive ventilation (NIV) with average volume-assured pressure support, a newer NIV modality, was used successfully to treat this patient, achieving major clinical and gas exchange improvement both during the hospitalization and long term after discharge.

Publication types

Case Reports