Primary, Secondary, and Tertiary Prevention of Congenital Cytomegalovirus Infection

Pauline Sartori; Charles Egloff; Najeh Hcini; Christelle Vauloup Fellous; Claire Périllaud-Dubois; Olivier Picone; Léo Pomar

doi:10.3390/v15040819

Primary, Secondary, and Tertiary Prevention of Congenital Cytomegalovirus Infection

Viruses. 2023 Mar 23;15(4):819. doi: 10.3390/v15040819.

Authors

Pauline Sartori^{1

2}, Charles Egloff^{3

4

5}, Najeh Hcini^{6

7}, Christelle Vauloup Fellous^{8

9

10}, Claire Périllaud-Dubois^{4

5

11}, Olivier Picone^{3

4

5

10}, Léo Pomar^{1

2}

Affiliations

¹ School of Health Sciences (HESAV), University of Applied Sciences and Arts Western Switzerland, 1011 Lausanne, Switzerland.
² Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
³ Assistance Publique-Hôpitaux de Paris APHP, Nord, Service de Gynécologie Obstétrique, Hôpital Louis Mourier, 92700 Colombes, France.
⁴ Université de Paris, 75006 Paris, France.
⁵ INSERM, IAME, B.P. 416, 75870 Paris, France.
⁶ Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, French 97320, Guyana.
⁷ CIC Inserm 1424 et DFR Santé Université Guyane, 97320 ST Laurent du Maroni, France.
⁸ Université Paris-Saclay, INSERM U1193, 94804 Villejuif, France.
⁹ Laboratoire de Virologie, AP-HP, Hôpital Paul-Brousse, 94804 Villejuif, France.
¹⁰ Groupe de Recherche sur les Infections Pendant la Grossesse (GRIG), 75000 Paris, France.
¹¹ Virology Laboratory, AP-HP, Sorbonne Université, Hôpital Saint-Antoine, F-75012 Paris, France.

Abstract

Cytomegalovirus infection is the most common congenital infection, affecting about 1% of births worldwide. Several primary, secondary, and tertiary prevention strategies are already available during the prenatal period to help mitigate the immediate and long-term consequences of this infection. In this review, we aim to present and assess the efficacy of these strategies, including educating pregnant women and women of childbearing age on their knowledge of hygiene measures, development of vaccines, screening for cytomegalovirus infection during pregnancy (systematic versus targeted), prenatal diagnosis and prognostic assessments, and preventive and curative treatments in utero.

Keywords: congenital infection; cytomegalovirus; prenatal diagnosis; prevention.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus Infections* / diagnosis
Cytomegalovirus Infections* / prevention & control
Female
Fetal Diseases*
Humans
Infectious Disease Transmission, Vertical / prevention & control
Pregnancy
Pregnancy Complications, Infectious* / diagnosis
Pregnancy Complications, Infectious* / prevention & control
Prenatal Diagnosis
Tertiary Prevention

Grants and funding

This research was funded by the grant AGP 117910 from the scientific commission of the University of Applied Sciences and Arts Western Switzerland (HES-SO).