Recent Advances in the Synthesis of Propargyl Derivatives, and Their Application as Synthetic Intermediates and Building Blocks

Rodrigo Abonia; Daniel Insuasty; Kenneth K Laali

doi:10.3390/molecules28083379

Recent Advances in the Synthesis of Propargyl Derivatives, and Their Application as Synthetic Intermediates and Building Blocks

Molecules. 2023 Apr 11;28(8):3379. doi: 10.3390/molecules28083379.

Authors

Rodrigo Abonia¹, Daniel Insuasty², Kenneth K Laali³

Affiliations

¹ Research Group of Heterocyclic Compounds, Department of Chemistry, Universidad del Valle, Cali A.A. 25360, Colombia.
² Grupo de Investigación en Química y Biología, Departamento de Química y Biología, Universidad del Norte, Barranquilla 081007, Atlántico, Colombia.
³ Department of Chemistry, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.

Abstract

The propargyl group is a highly versatile moiety whose introduction into small-molecule building blocks opens up new synthetic pathways for further elaboration. The last decade has witnessed remarkable progress in both the synthesis of propargylation agents and their application in the synthesis and functionalization of more elaborate/complex building blocks and intermediates. The goal of this review is to highlight these exciting advances and to underscore their impact.

Keywords: application in synthesis; catalysts and catalytic systems; homopropargylic reagents; propargylated building blocks and intermediates; propargylating agents; target substrates.

Publication types

Review

Grants and funding

This research received no external funding.