Involvement in Tumorigenesis and Clinical Significance of CXCL1 in Reproductive Cancers: Breast Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer and Prostate Cancer

Jan Korbecki; Mateusz Bosiacki; Katarzyna Barczak; Ryta Łagocka; Agnieszka Brodowska; Dariusz Chlubek; Irena Baranowska-Bosiacka

doi:10.3390/ijms24087262

Involvement in Tumorigenesis and Clinical Significance of CXCL1 in Reproductive Cancers: Breast Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer and Prostate Cancer

Int J Mol Sci. 2023 Apr 14;24(8):7262. doi: 10.3390/ijms24087262.

Authors

Jan Korbecki^{1

2}, Mateusz Bosiacki^{1

3}, Katarzyna Barczak⁴, Ryta Łagocka⁴, Agnieszka Brodowska⁵, Dariusz Chlubek¹, Irena Baranowska-Bosiacka¹

Affiliations

¹ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
² Department of Anatomy and Histology, Collegium Medicum, University of Zielona Góra, Zyty 28 Str., 65-046 Zielona Góra, Poland.
³ Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences Pomeranian Medical University in Szczecin, Żołnierska 54 Str., 71-210 Szczecin, Poland.
⁴ Department of Conservative Dentistry and Endodontics, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
⁵ Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.

Abstract

C-X-C motif chemokine ligand 1 (CXCL1) is a member of the CXC chemokine subfamily and a ligand for CXCR2. Its main function in the immune system is the chemoattraction of neutrophils. However, there is a lack of comprehensive reviews summarizing the significance of CXCL1 in cancer processes. To fill this gap, this work describes the clinical significance and participation of CXCL1 in cancer processes in the most important reproductive cancers: breast cancer, cervical cancer, endometrial cancer, ovarian cancer, and prostate cancer. The focus is on both clinical aspects and the significance of CXCL1 in molecular cancer processes. We describe the association of CXCL1 with clinical features of tumors, including prognosis, ER, PR and HER2 status, and TNM stage. We present the molecular contribution of CXCL1 to chemoresistance and radioresistance in selected tumors and its influence on the proliferation, migration, and invasion of tumor cells. Additionally, we present the impact of CXCL1 on the microenvironment of reproductive cancers, including its effect on angiogenesis, recruitment, and function of cancer-associated cells (macrophages, neutrophils, MDSC, and T_reg). The article concludes by summarizing the significance of introducing drugs targeting CXCL1. This paper also discusses the significance of ACKR1/DARC in reproductive cancers.

Keywords: CXCL1; breast cancer; cervical cancer; chemokine; endometrial cancer; ovarian cancer; prostate cancer.

Publication types

Review

MeSH terms

Breast Neoplasms*
Carcinogenesis
Cell Transformation, Neoplastic
Chemokine CXCL1 / genetics
Clinical Relevance
Endometrial Neoplasms* / genetics
Female
Humans
Ligands
Male
Ovarian Neoplasms*
Prostatic Neoplasms*
Receptors, Interleukin-8B
Tumor Microenvironment
Uterine Cervical Neoplasms* / genetics

Substances

Ligands
Chemokine CXCL1
Receptors, Interleukin-8B
CXCL1 protein, human

Grants and funding

This study was supported by the statutory budget of the Department of Biochemistry and Medical Chemistry Pomeranian Medical University in Szczecin, Poland.