Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma

Yosuk Min; Hong-Beom Park; Kwang-Hyun Baek; Sohyun Hwang

doi:10.3390/genes14040886

Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma

Genes (Basel). 2023 Apr 9;14(4):886. doi: 10.3390/genes14040886.

Authors

Yosuk Min¹, Hong-Beom Park¹, Kwang-Hyun Baek¹, Sohyun Hwang^{2

3}

Affiliations

¹ Department of Biomedical Science, CHA University, Seongnam 13488, Gyeonggi-do, Republic of Korea.
² Department of Pathology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Gyeonggi-do, Republic of Korea.
³ CHA Future Medicine Research Institute, CHA Bundang Medical Center, Seongnam 13496, Gyeonggi-do, Republic of Korea.

Abstract

In ovarian cancer patients, the 5-year survival rate is 90% for stages I and II, but only 30% for stages III and IV. Unfortunately, as 75% of the patients are diagnosed at stages III and IV, many experience a recurrence. To ameliorate this, it is necessary to develop new biomarkers for early diagnosis and treatment. The ubiquitin-proteasome system is a post-translational modification that plays an important role in regulating protein stability through ubiquitination. In particular, deubiquitinating enzymes (DUBs) regulate protein stability through deubiquitinating substrate proteins. In this review, DUBs and substrates regulated by these enzymes are summarized based on their functions in ovarian cancer cells. This would be useful for the discovery of biomarkers for ovarian cancer and developing new therapeutic candidates.

Keywords: deubiquitinating enzyme; epithelial ovarian cancer; ubiquitin–proteasome system.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma*
Deubiquitinating Enzymes / genetics
Deubiquitinating Enzymes / metabolism
Female
Humans
Ovarian Neoplasms* / genetics
Ubiquitin / metabolism
Ubiquitination

Substances

Ubiquitin
Deubiquitinating Enzymes

Grants and funding

This work was funded by a grant (No. HI16C1559) from the Korea Health Technology R&D Project through The Korea Health Industry Development Institute (KHIDI); the Basic Science Research Program through the National Research Foundation of Korea (NRF) with a grant (No. NRF-2019R1A6A1A03032888) funded by the Ministry of Education; and supported by the NRF grant (No. 2022R1A2C109179712) funded by the Ministry of Science and ICT (MSIT).