Cysteine-rich receptor-like protein kinases: emerging regulators of plant stress responses

Yongxue Zhang; Haodong Tian; Daniel Chen; Heng Zhang; Meihong Sun; Sixue Chen; Zhi Qin; Zhaojun Ding; Shaojun Dai

doi:10.1016/j.tplants.2023.03.028

Cysteine-rich receptor-like protein kinases: emerging regulators of plant stress responses

Trends Plant Sci. 2023 Jul;28(7):776-794. doi: 10.1016/j.tplants.2023.03.028. Epub 2023 Apr 26.

Authors

Yongxue Zhang¹, Haodong Tian², Daniel Chen³, Heng Zhang², Meihong Sun², Sixue Chen⁴, Zhi Qin⁵, Zhaojun Ding⁶, Shaojun Dai⁷

Affiliations

¹ Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China; Shanghai Key Laboratory of Protected Horticulture Technology, Horticultural Research Institute, Shanghai Academy of Agricultural Science, Shanghai 201403, China.
² Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China.
³ MD Program of Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
⁴ Department of Biology, The University of Mississippi, Oxford, MS 38677, USA.
⁵ Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China. Electronic address: qinzhi@shnu.edu.cn.
⁶ Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, Shandong, China. Electronic address: dingzhaojun@sdu.edu.cn.
⁷ Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China. Electronic address: daishaojun@shnu.edu.cn.

PMID: 37105805
DOI: 10.1016/j.tplants.2023.03.028

Abstract

Cysteine-rich receptor-like kinases (CRKs) belong to a large DUF26-containing receptor-like kinase (RLK) family. They play key roles in immunity, abiotic stress response, and growth and development. How CRKs regulate diverse processes is a long-standing question. Recent studies have advanced our understanding of the molecular mechanisms underlying CRK functions in Ca²⁺ influx, reactive oxygen species (ROS) production, mitogen-activated protein kinase (MAPK) cascade activation, callose deposition, stomatal immunity, and programmed cell death (PCD). We review the CRK structure-function relationship with a focus on the roles of CRKs in immunity, the abiotic stress response, and the growth-stress tolerance tradeoff. We provide a critical analysis and synthesis of how CRKs control sophisticated regulatory networks that determine diverse plant phenotypic outputs.

Keywords: abiotic stress; cysteine-rich receptor-like kinase; emerging regulator; growth and development; immunity; phytohormone.

Publication types

Review

MeSH terms

Arabidopsis* / metabolism
Cysteine / metabolism
Gene Expression Regulation, Plant
Plants / genetics
Plants / metabolism
Protein Kinases / genetics
Protein Kinases / metabolism
Protein Serine-Threonine Kinases / genetics

Substances

Cysteine
Protein Serine-Threonine Kinases
Protein Kinases