Oral Immunotherapy: An Overview

Krista Todoric; Sarah Merrill

doi:10.1016/j.pop.2022.11.006

Oral Immunotherapy: An Overview

Prim Care. 2023 Jun;50(2):269-281. doi: 10.1016/j.pop.2022.11.006. Epub 2023 Feb 26.

Authors

Krista Todoric¹, Sarah Merrill²

Affiliations

¹ Medical Arts Allergy, 220 Wilson Street Suite 200, Carlisle, PA 17013, USA. Electronic address: ktodorich@gmail.com.
² Family Medicine Department, UC San Diego Health, 402 Dickinson Street, San Diego, CA 92103, USA.

PMID: 37105606
DOI: 10.1016/j.pop.2022.11.006

Abstract

Oral immunotherapy (OIT) is an alternative treatment of IgE-mediated food allergy that has been shown to increase tolerance threshold to many of the top food allergens, although this effect may be dependent on age, dose, frequency, and duration. OIT has been shown to be effective and safe in infants, and early initiation can improve rates of desensitization even for those foods whose natural history favors loss of allergy. Studies looking at protocol modification to improve OIT success are ongoing as is the evaluation of clinical tools to help monitor OIT effects.

Keywords: Egg; Food allergy; Milk; OIT; Oral immunotherapy; Peanut; Sustained unresponsiveness; Tolerance.

Publication types

Review

MeSH terms

Administration, Oral
Allergens
Arachis
Desensitization, Immunologic / methods
Food Hypersensitivity* / therapy
Humans
Immunoglobulin E
Infant
Peanut Hypersensitivity* / therapy

Substances

Allergens
Immunoglobulin E