Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

Vladimir Kanygin; Alexander Zaboronok; Aleksandr Kichigin; Elena Petrova; Tatyana Guselnikova; Andrey Kozlov; Dmitriy Lukichev; Bryan J Mathis; Sergey Taskaev

doi:10.3390/vetsci10040274

Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

Vet Sci. 2023 Apr 4;10(4):274. doi: 10.3390/vetsci10040274.

Authors

Vladimir Kanygin^{1

2}, Alexander Zaboronok³, Aleksandr Kichigin^{1

2}, Elena Petrova⁴, Tatyana Guselnikova^{2

5}, Andrey Kozlov⁶, Dmitriy Lukichev², Bryan J Mathis⁷, Sergey Taskaev^{1

2}

Affiliations

¹ Budker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, ave. Lavrentiev, 11, 630090 Novosibirsk, Russia.
² Laboratory of Nuclear and Innovative Medicine, Department of Physics, Novosibirsk State University, Pirogov str., 1, 630090 Novosibirsk, Russia.
³ Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba 305-8575, Ibaraki, Japan.
⁴ Veterinary Clinic "Best", Frunze str., 57, 630005 Novosibirsk, Russia.
⁵ Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, ave. Lavrentiev, 3, 630090 Novosibirsk, Russia.
⁶ Clinical Hospital "Avicenna", Uritskogo str., 2, 630007 Novosibirsk, Russia.
⁷ International Medical Center, University of Tsukuba Hospital, Amakubo 2-1-1, Tsukuba 305-8576, Ibaraki, Japan.

Abstract

We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist^®, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.

Keywords: BNCT; Gd-DTPA; GdNCT; boron neutron capture therapy; cancer; dimeglumine gadopentetate; gadolinium neutron capture therapy; large animal irradiation; spontaneous tumors; veterinary medicine.

Abstract

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