Application of Magnetic Resonance Strain Analysis Using Feature Tracking in a Myocardial Infarction Model

Ryutaro Onishi; Junpei Ueda; Seiko Ide; Masahiro Koseki; Yasushi Sakata; Shigeyoshi Saito

doi:10.3390/tomography9020071

Application of Magnetic Resonance Strain Analysis Using Feature Tracking in a Myocardial Infarction Model

Tomography. 2023 Apr 18;9(2):871-882. doi: 10.3390/tomography9020071.

Authors

Ryutaro Onishi^{1

2}, Junpei Ueda¹, Seiko Ide³, Masahiro Koseki³, Yasushi Sakata³, Shigeyoshi Saito^{1

4}

Affiliations

¹ Department of Medical Physics and Engineering, Area of Medical Imaging Technology and Science, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
² Division of Clinical Radiology Service, Kyoto University Hospital, Kyoto 606-8507, Japan.
³ Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
⁴ Department of Advanced Medical Technologies, National Cerebral and Cardiovascular Center Research Institute, Osaka 564-8565, Japan.

Abstract

This study validates the usefulness of myocardial strain analysis with cardiac cine magnetic resonance imaging (MRI) by evaluating the changes in the cardiac function and myocardial strain values longitudinally in a myocardial disease model. Six eight-week-old male Wistar rats were used as a model of myocardial infarction (MI). Cine images were taken in the short axis, two-chamber view longitudinal axis, and four-chamber view longitudinal axis directions in rats 3 and 9 days after MI and in control rats, with preclinical 7-T MRI. The control images and the images on days 3 and 9 were evaluated by measuring the ventricular ejection fraction (EF) and the strain values in the circumferential (CS), radial (RS), and longitudinal directions (LS). The CS decreased significantly 3 days after MI, but there was no difference between the images on days 3 and 9. The two-chamber view LS was -9.7 ± 2.1% at 3 days and -13.9 ± 1.4% at 9 days after MI. The four-chamber view LS was -9.9 ± 1.5% at 3 days and -11.9 ± 1.3% at 9 days after MI. Both the two- and four-chamber LS values were significantly decreased 3 days after MI. Myocardial strain analysis is, therefore, useful for assessing the pathophysiology of MI.

Keywords: 7T-MRI; MR strain analysis; myocardial infarction model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Magnetic Resonance Imaging*
Magnetic Resonance Imaging, Cine / methods
Magnetic Resonance Spectroscopy
Male
Myocardial Infarction* / diagnostic imaging
Rats
Rats, Wistar

Grants and funding

This research was funded by the Japan Society for the Promotion of Science (JSPS) KA-KENHI (grant number 19K08172) and the Agency for Medical Research and Development (AMED) (grant numbers JP19dm0307026 and 20dm0307026h00030). This work was the result of using research equipment shared by the MEXT Project for promoting the public utilization of advanced research infrastructure (program for supporting the construction of core facilities) (grant numbers JPMXS0450400021, JPMXS0450400022, and JPMXS0450400023).