Metabolic profile in women with bulimia nervosa or binge-eating disorder before and after treatment: secondary analysis from the randomized PED-t trial

Therese Fostervold Mathisen; Jorunn Sundgot-Borgen; Jan H Rosenvinge; Solfrid Bratland-Sanda; Mette Svendsen; Gunn Pettersen; KariAnne Vrabel; Oddgeir Friborg

doi:10.1007/s40519-023-01567-y

Metabolic profile in women with bulimia nervosa or binge-eating disorder before and after treatment: secondary analysis from the randomized PED-t trial

Eat Weight Disord. 2023 Apr 27;28(1):41. doi: 10.1007/s40519-023-01567-y.

Authors

Therese Fostervold Mathisen¹, Jorunn Sundgot-Borgen², Jan H Rosenvinge³, Solfrid Bratland-Sanda⁴, Mette Svendsen⁵, Gunn Pettersen⁶, KariAnne Vrabel^{3

7}, Oddgeir Friborg³

Affiliations

¹ Faculty of Health, Welfare and Organisation, Østfold University College, Fredrikstad, Norway. theresfm@hiof.no.
² Institute of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
³ Department of Psychology, Faculty of Health Sciences, UIT, The Arctic University of Norway, Tromsø, Norway.
⁴ Department of Outdoor Studies, Sports and Physical Education, University of South-Eastern Norway, Bø, Norway.
⁵ Department of Endocrinology, Obesity and Preventive Medicine, Oslo University Hospital and Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
⁶ Department of Health and Caring Sciences, Faculty of Health Sciences, UIT, The Arctic University of Norway, Tromsø, Norway.
⁷ Department of Psychology, Research Institute of Modum Bad, Vikersund, Norway.

Abstract

Purpose: Chaotic eating and purging behavior pose a risk to the metabolic health of women with bulimia nervosa (BN) and binge-eating disorder (BED). This study reports on one-year changes in blood markers of metabolic health and thyroid hormones in women with BN or BED attending two different treatments.

Methods: These are secondary analyses from a randomized controlled trial of 16-week group treatment of either physical exercise and dietary therapy (PED-t) or cognitive behavior therapy (CBT). Blood samples collected at pre-treatment, week eight, post-treatment, and at 6- and 12-month follow-ups were analyzed for glucose, lipids (triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-c), HDL cholesterol (HDL-c), apolipoprotein A (ApoA) and apolipoprotein B (ApoB) lipoproteins), and thyroid hormones (thyroxine (T4), thyroid stimulating hormone (TSH), and thyroperoxidase antibodies).

Result: The average levels of blood glucose, lipids and thyroid hormones were within the recommended range, but clinical levels of TC and LDL-c were detected in 32.5% and 39.1%, respectively. More women with BED compared with BN had low HDL-c, and a larger increase over time in TC and TSH. No significant differences occurred between PED-t and CBT at any measurement. Exploratory moderator analyses indicated a more unfavorable metabolic response at follow-up among treatment non-responders.

Conclusion: The proportion of women with impaired lipid profiles and unfavorable lipid changes, suggests active monitoring with necessary management of the metabolic health of women with BN or BED, as recommended by metabolic health guidelines.

Level of evidence: Level I: Evidence obtained from a randomized, experimental trial.

Trial registration number: This trial was prospectively registered in the Norwegian Regional Committee for Medical and Health Research Ethics on December 16, 2013, with the identifier number 2013/1871, and in Clinical Trials on February 17, 2014, with the identifier number NCT02079935.

Keywords: Binge-eating disorder; Blood glucose; Bulimia nervosa; Cholesterol; Physical health; Thyroid hormone.

Publication types

Randomized Controlled Trial

MeSH terms

Apolipoproteins
Binge-Eating Disorder* / psychology
Binge-Eating Disorder* / therapy
Bulimia Nervosa* / psychology
Bulimia Nervosa* / therapy
Cholesterol, LDL
Exercise / psychology
Female
Humans
Metabolome

Substances

Cholesterol, LDL
Apolipoproteins

Associated data

ClinicalTrials.gov/NCT02079935