Green ecofriendly electrochemical sensing platform for the sensitive determination of doxycycline

Aml M Asran; Mona A Mohamed; Mohamed K Abd El-Rahman; Maral P S Mousavi

doi:10.1016/j.heliyon.2023.e15223

Green ecofriendly electrochemical sensing platform for the sensitive determination of doxycycline

Heliyon. 2023 Apr 5;9(4):e15223. doi: 10.1016/j.heliyon.2023.e15223. eCollection 2023 Apr.

Authors

Aml M Asran^{1

2}, Mona A Mohamed^{3

4}, Mohamed K Abd El-Rahman⁵, Maral P S Mousavi⁴

Affiliations

¹ Deanship of the Common First Year, Jouf University, El-Jouf, Saudi Arabia.
² Faculty of Engineering, Modern Academy for Technology and Engineering, Cairo, Egypt.
³ Pharmaceutical Chemistry Department, Egyptian Drug Authority, Giza, Egypt.
⁴ Biomedical Engineering, University of Southern California, Los Angeles, United States.
⁵ Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo, 11562, Egypt.

Abstract

The detection of pharmaceutical compounds in extremely low concentrations remains a challenge despite recent advancements in electrochemical sensing. In this study, a green hydrothermally synthesized nickel hydroxide-graphene hybrid material was used for the point-of-care determination of the antibiotic doxycycline (DOXY), which is a promising treatment for COVID-19 and other infections. The electrochemical sensor, based on a screen-printed electrode modified with the hybrid material, was able to detect DOXY in the range of 5.1 × 10^-8 to 1.0 × 10^-4 M, with a low detection limit of 9.6 × 10^-9 M. This approach paves the way for eco-friendly and sustainable methods of nanomaterial synthesis for electrochemical analyses, particularly in point-of-care drug monitoring, and has the potential to improve access to testing platforms.

Keywords: Co-administered drugs; Doxycycline; Drug therapeutic window; Electrochemical sensor; Green synthesis; Nanocomposite; Point-of-care sensors.