A metabolic clue for STING suppression

Yifan Zhang; Ming-Zhu Lei; Miao Yin; Qun-Ying Lei

doi:10.1016/j.tcb.2023.04.003

A metabolic clue for STING suppression

Trends Cell Biol. 2023 Jul;33(7):536-537. doi: 10.1016/j.tcb.2023.04.003. Epub 2023 Apr 24.

Authors

Yifan Zhang¹, Ming-Zhu Lei¹, Miao Yin¹, Qun-Ying Lei²

Affiliations

¹ Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China; Department of Oncology, Cancer Institutes, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
² Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China; Department of Oncology, Cancer Institutes, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China; State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, People's Republic of China. Electronic address: qlei@fudan.edu.cn.

PMID: 37100634
DOI: 10.1016/j.tcb.2023.04.003

Abstract

A recent report by Heath et al. reveals that obesity could impair cancer immunogenicity and foster a type I interferon (IFN-I)-deprived tumor microenvironment through saturated fatty acid-mediated stimulator of interferon genes (STING) inhibition.

Keywords: STING; antitumor immunity; fatty acids; obesity.

MeSH terms

Humans
Interferon Type I*
Neoplasms* / pathology
Tumor Microenvironment

Substances

Interferon Type I

Abstract

MeSH terms

Substances

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