The beauty of seeing the real thing: BMP heterodimer detection in vivo reveals dimer composition and activity

Giovanna M Collu; Marek Mlodzik

doi:10.1016/j.devcel.2023.03.022

The beauty of seeing the real thing: BMP heterodimer detection in vivo reveals dimer composition and activity

Dev Cell. 2023 Apr 24;58(8):633-634. doi: 10.1016/j.devcel.2023.03.022.

Authors

Giovanna M Collu¹, Marek Mlodzik²

Affiliations

¹ Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² Department of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: marek.mlodzik@mssm.edu.

PMID: 37098324
DOI: 10.1016/j.devcel.2023.03.022

Abstract

BMP family ligands can direct cells to divide, differentiate, or die, depending on cell context and specific hetero- or homodimer combinations. In this issue of Developmental Cell, Bauer et al. detect endogenous Drosophila ligand dimers in situ and show that BMP dimer composition affects both signaling range and activity.

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MeSH terms

Animals
Bone Morphogenetic Proteins*
Drosophila / metabolism
Drosophila Proteins* / metabolism
Ligands
Signal Transduction

Substances

Bone Morphogenetic Proteins
Drosophila Proteins
Ligands