Foreshadowing future needs has catapulted the progress of skin-like electronic devices for human-machine interactions. These devices possess human skin-like properties such as stretchability, self-healability, transparency, biocompatibility, and wearability. This review highlights the recent progress in a promising material, MXenes, to realize soft, deformable, skin-like electrodes. Various structural designs, fabrication strategies, and rational guidelines adopted to realize MXene-based skin-like electrodes are outlined. We explicitly discussed machine learning-based material informatics to understand and predict the properties of MXenes. Finally, an outlook on the existing challenges and the future roadmap to realize soft skin-like MXene electrodes to facilitate technological advances in the next-generation human-machine interactions has been described.