Pregnancy vaccination predictive factors and uptake profiles among Italian women: A cross-sectional survey study on a large population

Int J Gynaecol Obstet. 2023 Jul;162(1):105-115. doi: 10.1002/ijgo.14797. Epub 2023 Apr 24.

Abstract

Objectives: To assess influenza and Tdap (tetanus, diphtheria, pertussis) vaccine coverage during pregnancy, explore key socioeconomic and maternity pathway-related predictors of vaccination, and detect specific patterns of vaccination uptake.

Methods: The authors cross-sectionally analyzed self-reported data obtained from the systematic survey on the maternity pathways of Tuscany. They selected all pregnant women that completed from March 2019 to June 2022 the third-trimester questionnaire (n = 25 160), which included two dichotomous items on influenza and Tdap vaccination, as well as socioeconomic and pathway-related questions. Multilevel logistic models were performed to assess vaccination predictors and cluster analysis to identify vaccination patterns.

Results: Vaccination coverage was higher for pertussis (56.5%) than for influenza (18.9%). The main predictors of vaccination were high socioeconomic status, attending private gynecologists, and receiving vaccine information. Three clusters were identified: cluster 1 included women receiving both Tdap and influenza vaccines; cluster 2 included women receiving no vaccinations; and cluster 3 included women receiving only the pertussis vaccine. Although women from cluster 3 were of middle to low education status, vaccine information was the main adherence determinant also in this group.

Conclusions: Health workers and policymakers should focus on groups of pregnant women less prone to vaccination to promote vaccination information and encourage wider uptake and coverage.

Keywords: Italy; influenza; patient-reported data; pertussis; pregnancy; vaccine/vaccination.

MeSH terms

  • Cross-Sectional Studies
  • Diphtheria-Tetanus-acellular Pertussis Vaccines*
  • Female
  • Humans
  • Influenza Vaccines*
  • Influenza, Human* / prevention & control
  • Pregnancy
  • Surveys and Questionnaires
  • Whooping Cough* / prevention & control

Substances

  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Influenza Vaccines