Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction

Ruimin Liu; Yinying Han; Chenglong Huang; Mengqian Hou; Rui Cheng; Shujin Wang; Xi Li; Jie Tian

doi:10.1016/j.isci.2023.106495

Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction

iScience. 2023 Mar 24;26(4):106495. doi: 10.1016/j.isci.2023.106495. eCollection 2023 Apr 21.

Authors

Ruimin Liu^{1

2}, Yinying Han², Chenglong Huang³, Mengqian Hou², Rui Cheng², Shujin Wang², Xi Li², Jie Tian¹

Affiliations

¹ Department of Cardiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400032, PR China.
² Biology Science Institutes, Chongqing Medical University, Chongqing 400032, PR China.
³ Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing 400032, PR China.

Abstract

Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked to metabolic syndrome and cardiac function in obese and diabetes mellitus. This study aimed to investigate the potential roles of adipokine chemerin on high fat-induced cardiac dysfunction. Chemerin (Rarres2) knockout mice, which were fed with either a normal diet or a high-fat diet for 20 weeks, were employed to observe whether adipokine chemerin affected lipid metabolism, inflammation, and cardiac function. Firstly, we found normal metabolic substrate inflexibility and cardiac function in Rarres2 ^-/- mice with a normal diet. Notably, in a high-fat diet, Rarres2 ^-/- mice showed lipotoxicity, insulin resistance, and inflammation, thus causing metabolic substrate inflexibility and cardiac dysfunction. Furthermore, by using in vitro model of lipid-overload cardiomyocytes, we found chemerin supplementation reversed the lipid-induced abnormalities above. Herein, in the presence of obesity, adipocyte-derived chemerin might function as an endogenous cardioprotective factor against obese-related cardiomyopathy.

Keywords: Cell biology; Cellular physiology; Physiology.