Risk factors of epilepsy secondary to viral encephalitis: A meta-analysis

J Neuroimmunol. 2023 May 15:378:578089. doi: 10.1016/j.jneuroim.2023.578089. Epub 2023 Apr 11.

Abstract

Objective: To systematically evaluate the risk factors of post-encephalitis epilepsy (PEE).

Methods: Systematic computerized searches of databases such as Cochrane Library, PubMed and EMBASE were performed. The meta-analysis of pooled odds ratios and 95% confidence intervals for PEE risk were calculated.

Results: Sixteen studies with 2504 patients were included for meta-analysis. The results showed that PEE was associated with coma, seizure, status epilepticus, cranial MRI abnormality, focal EEG abnormality, and positive herpes simplex virus (HSV) in cerebrospinal fluid (CSF).

Conclusion: Coma, seizures or status epilepticus, abnormal MRI and focal EEG, and HSV in CSF were the risk factors of PEE.

Keywords: Epilepsy; Risk factors; Seizure; Viral encephalitis; meta-analysis.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Coma / complications
  • Encephalitis* / complications
  • Encephalitis, Herpes Simplex*
  • Encephalitis, Viral* / complications
  • Encephalitis, Viral* / diagnostic imaging
  • Epilepsy* / diagnostic imaging
  • Epilepsy* / epidemiology
  • Epilepsy* / etiology
  • Humans
  • Risk Factors
  • Seizures
  • Status Epilepticus* / etiology