Objective: To systematically evaluate the risk factors of post-encephalitis epilepsy (PEE).
Methods: Systematic computerized searches of databases such as Cochrane Library, PubMed and EMBASE were performed. The meta-analysis of pooled odds ratios and 95% confidence intervals for PEE risk were calculated.
Results: Sixteen studies with 2504 patients were included for meta-analysis. The results showed that PEE was associated with coma, seizure, status epilepticus, cranial MRI abnormality, focal EEG abnormality, and positive herpes simplex virus (HSV) in cerebrospinal fluid (CSF).
Conclusion: Coma, seizures or status epilepticus, abnormal MRI and focal EEG, and HSV in CSF were the risk factors of PEE.
Keywords: Epilepsy; Risk factors; Seizure; Viral encephalitis; meta-analysis.
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