Long-term results of autologous periosteum-derived micro-grafts with poly(lactic-go-glycolic acid) in sinus lift augmentation surgeries: A 7-years follow-up observational study

Elisa Paolin; Gabriele Ceccarelli; Ruggero Rodriguez Y Baena; Luigi D'Urso; Claudia Todaro; Saturnino Marco Lupi

doi:10.1016/j.ijscr.2023.108153

Long-term results of autologous periosteum-derived micro-grafts with poly(lactic-go-glycolic acid) in sinus lift augmentation surgeries: A 7-years follow-up observational study

Int J Surg Case Rep. 2023 May:106:108153. doi: 10.1016/j.ijscr.2023.108153. Epub 2023 Apr 14.

Authors

Elisa Paolin¹, Gabriele Ceccarelli², Ruggero Rodriguez Y Baena³, Luigi D'Urso⁴, Claudia Todaro⁵, Saturnino Marco Lupi⁶

Affiliations

¹ Department of Public Health, Experimental and Forensic Medicine, Human Anatomy Unit, University of Pavia, Pavia, Italy; Human Brain Wave, Turin, Italy. Electronic address: elisa.paolin01@universitadipavia.it.
² Department of Public Health, Experimental and Forensic Medicine, Human Anatomy Unit, University of Pavia, Pavia, Italy. Electronic address: gabriele.ceccarelli@unipv.it.
³ School of Dentistry, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. Electronic address: ruggero.rodriguez@unipv.it.
⁴ School of Dentistry, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. Electronic address: luigi.durso01@universitadipavia.it.
⁵ School of Dentistry, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. Electronic address: claudia.todaro01@ateneopv.it.
⁶ School of Dentistry, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. Electronic address: saturninomarco.lupi@unipv.it.

Abstract

Introduction and importance: The study aimed to present the long-term results of autologous and homologous micrografts for bone regeneration aimed at positioning dental implants after sinus lift augmentation surgeries, by combining autologous Rigenera® micrografts with poly(lactic-go-glycolic acid).

Case presentation: A total of 5 patients (2 males and 3 females) from 36 to 71 years were involved in the observational study. All the patients showed a good health status system (ASA1 and 2), according to their clinical history with neither system diseases, nor under medication able to interfere with osseointegration.

Clinical discussion: The radiographic evaluations, after the implant placement and during the continuous follow-up upto 7 years, were carried out through periapical endoral x-rays. The survival and implant success rate was 100 %. Histological analyses were performed after 3 and 7 months after the surgical procedure.

Conclusion: No adverse events have been observed that can be traced back to the use of autologous micrografts with poly(lactic-go-glycolic acid), showing safety and predictable results even in long term.

Keywords: Micrografts; Periosteum-derived progenitor cells; Poly(lactic-co-glycolic) acid-based materials; Sinus lift augmentation; Tissue engineering.