Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature

Shaqayeq Ramezanzade; Mahsa Aeinehvand; Heliya Ziaei; Zohaib Khurshid; Seied Omid Keyhan; Hamid R Fallahi; James C Melville; Morvarid Saeinasab; Farshid Sefat

doi:10.3390/biomimetics8020142

Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature

Biomimetics (Basel). 2023 Mar 30;8(2):142. doi: 10.3390/biomimetics8020142.

Authors

Shaqayeq Ramezanzade¹, Mahsa Aeinehvand², Heliya Ziaei², Zohaib Khurshid^{3

4}, Seied Omid Keyhan⁵, Hamid R Fallahi⁵, James C Melville⁶, Morvarid Saeinasab⁷, Farshid Sefat⁷

Affiliations

¹ Section for Clinical Oral Microbiology, Department of Odontology Cariology and Endodontics, University of Copenhagen, DK-2200 Copenhagen, Denmark.
² Maxillofacial Surgery & Implantology & Biomaterial Research Foundation, Tehran P.O. Box 14155-6559, Iran.
³ Department of Prosthodontics and Dental Implantology, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
⁴ Center of Excellence for Regenerative Dentistry, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.
⁵ Maxillofacial Surgery & Implantology & Biomaterial Research Foundation, Isfahan P.O. Box 61355-45, Iran.
⁶ Oral, Head & Neck Oncology and Microvascular Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
⁷ Department of Biomedical and Electronic Engineering, School of Engineering, University of Bradford, Bradford BD7 1DP, UK.

Abstract

The current review aimed to assess the reliability and efficacy of tissue-engineered composite grafts in the reconstruction of large maxillofacial defects resulting from trauma or a benign pathologic disease. A systematic review of the literature was conducted using PubMed/Medline, Embase, and Scopus up to March 2022. The eligibility criteria included patients who had been treated with composite allogeneic tissue engineering for immediate/delayed reconstruction of large maxillofacial defects with minimum/no bone harvesting site. In the initial search, 2614 papers were obtained, and finally, 13 papers were eligible to be included in the current study. Most included papers were case reports or case series. A total of 144 cases were enrolled in this systematic review. The mean age of the patients was 43.34 (age range: 9-89). Most studies reported a successful outcome. Bone tissue engineering for the reconstruction and regeneration of crucial-sized maxillofacial defects is an evolving science still in its infancy. In conclusion, this review paper and the current literature demonstrate the potential for using large-scale transplantable, vascularized, and customizable bone with the aim of reconstructing the large maxillofacial bony defects in short-term follow-ups.

Keywords: composite graft; maxillofacial defects; tissue engineering.

Publication types

Review

Grants and funding

This research received no external funding.