Mycobacterium Avium Complex Infection of the Spine in a Patient Without Acquired Immune Deficiency Syndrome: A Case Report and Literature Review

Hui Lv; Jian Hong Zhou; Yuan Guo; Hui Chen; Jian Zhong Xu; Zhong Rong Zhang; Ze Hua Zhang

doi:10.1111/os.13736

Mycobacterium Avium Complex Infection of the Spine in a Patient Without Acquired Immune Deficiency Syndrome: A Case Report and Literature Review

Orthop Surg. 2023 Jun;15(6):1707-1715. doi: 10.1111/os.13736. Epub 2023 Apr 24.

Authors

Hui Lv^{1

2}, Jian Hong Zhou^{1

2}, Yuan Guo^{1

2}, Hui Chen^{1

2}, Jian Zhong Xu^{1

2}, Zhong Rong Zhang^{1

2}, Ze Hua Zhang^{1

2}

Affiliations

¹ Department of Orthopaedic, Jiangbei Branch of Southwest Hospital, 958th Hospital of the PLA Army, No. 29 Jianxin East Road, Jiangbei District, Chongqing, 400000, China.
² Department of Orthopaedic, Southwest Hospital, The First Affiliated Hospital of Army Medical University, No. 30 Gaotanyan Zhengjie, Shapingba District, Chongqing, 400038, China.

Abstract

A 52-year-old patient misdiagnosed with spinal tuberculosis was successfully diagnosed with Mycobacterium avium infection using metagenomic next-generation sequencing and cured with four-drug combination protocol chemotherapy (amikacin, rifampicin, clarithromycin, ethambutol) and spinal fixation.

Keywords: Case Report; Metagenomic Next Generation Sequencing; Mycobacterium Avium Complex; Spinal Infection; Spine.

Publication types

Review
Case Reports

MeSH terms

Acquired Immunodeficiency Syndrome* / drug therapy
Anti-Bacterial Agents / therapeutic use
Clarithromycin / therapeutic use
Drug Therapy, Combination
Humans
Middle Aged
Mycobacterium avium Complex
Mycobacterium avium-intracellulare Infection* / diagnosis
Mycobacterium avium-intracellulare Infection* / drug therapy
Mycobacterium avium-intracellulare Infection* / microbiology
Rifampin / therapeutic use

Substances

Clarithromycin
Rifampin
Anti-Bacterial Agents