Histologic Assessment of Thromboemboli Due to Plaque Rupture, Plaque Erosion, or COVID-19 Microthrombi

Takao Konishi; Kenji Kawai; Rika Kawakami; Saikat Kumar B Ghosh; Aimee E Vozenilek; Arielle Bellissard; Weili Xu; Renu Virmani; Aloke V Finn

doi:10.1016/j.jaccas.2023.101826

Histologic Assessment of Thromboemboli Due to Plaque Rupture, Plaque Erosion, or COVID-19 Microthrombi

JACC Case Rep. 2023 May 17:14:101826. doi: 10.1016/j.jaccas.2023.101826. Epub 2023 Apr 19.

Authors

Takao Konishi¹, Kenji Kawai¹, Rika Kawakami¹, Saikat Kumar B Ghosh¹, Aimee E Vozenilek¹, Arielle Bellissard¹, Weili Xu¹, Renu Virmani¹, Aloke V Finn^{1

2}

Affiliations

¹ CVPath Institute, Gaithersburg, Maryland, USA.
² University of Maryland, School of Medicine, Baltimore, Maryland, USA.

Abstract

Plaque rupture, plaque erosion, and COVID-19 infection can cause acute coronary syndromes (ACS). We illustrate case examples demonstrating the distinctive and characteristic pathologic findings underlying each of these various causes of acute myocardial infarction. A deeper understanding of the pathophysiology of ACS is necessary for the development of newer agents and techniques to improve outcomes after ACS. (Level of Difficulty: Advanced.).

Keywords: acute coronary syndrome; cardiovascular disease; myocardial infarction; thrombus.

Publication types

Case Reports