PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action

Haochen Wang; Jianbang Su; Minghao Yu; Yang Xia; Yingliang Wei

doi:10.3389/fphar.2023.1169019

PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action

Front Pharmacol. 2023 Apr 6:14:1169019. doi: 10.3389/fphar.2023.1169019. eCollection 2023.

Authors

Haochen Wang¹, Jianbang Su¹, Minghao Yu¹, Yang Xia², Yingliang Wei¹

Affiliations

¹ Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
² Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.

Abstract

Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exert a chondroprotective effect. PGC-1α delays the development and progression of OA by affecting mitochondrial biogenesis, oxidative stress, mitophagy and mitochondrial DNA (mtDNA) replication in chondrocytes. In addition, PGC-1α can regulate the metabolic abnormalities of OA chondrocytes and inhibit chondrocyte apoptosis. In this paper, we review the regulatory mechanisms of PGC-1α and its effects on OA chondrocytes, and introduce potential drugs and novel nanohybrid for the treatment of OA which act by affecting the activity of PGC-1α. This information will help to further elucidate the pathogenesis of OA and provide new ideas for the development of therapeutic strategies for OA.

Keywords: PGC- 1α; apoptosis; chondrocyte; metabolism; mitochondria; osteoarthritis.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant number 31900847), the China Postdoctoral Science Foundation (grant number 2019M66169), the Liaoning Province Doctoral Start-up Fund (grant number 2019JH3/10100299), the 345 Talent Project of Shengjing Hospital of China Medical University (grant number M0271).