A review of the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity of codonopsis radix

Jiaojiao Dong; Yexin Na; Ajiao Hou; Shihao Zhang; Huan Yu; Senwang Zheng; Wei Lan; Liu Yang

doi:10.3389/fphar.2023.1162036

A review of the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity of codonopsis radix

Front Pharmacol. 2023 Apr 6:14:1162036. doi: 10.3389/fphar.2023.1162036. eCollection 2023.

Authors

Jiaojiao Dong¹, Yexin Na¹, Ajiao Hou¹, Shihao Zhang¹, Huan Yu¹, Senwang Zheng¹, Wei Lan², Liu Yang¹

Affiliations

¹ Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China.
² College of Traditional Chinese Medicine, Ministry of Education, Xinjiang Medical University, Xinjiang, China.

Abstract

Codonopsis Radix, a traditional Chinese medicine in China, has great medicinal and scientific value. Moreover, it can also be used as a health product in daily diet. This paper reviews the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity related to Codonopsis Radix. The information of Codonopsis Radix is obtained from scientific databases (such as Baidu Scholar, CNKI, Google Scholar, PubMed, Science Direct, Web of Science, and SciFinder Scholar), Chinese herbal classics, Chinese Pharmacopoeia, PhD and MSc dissertations, and so on. The chemical components mainly include alkaloids, alkynes and polyacetylenes, flavonoids, lignans, steroids, terpenoids, organic acids, volatile oils, saccharides and other components, which have a wide range of neuroprotective effects, protection of gastrointestinal mucosa and anti-ulcer, regulation of body immunity, anti-tumor, endocrine regulation, improvement of hematopoietic function, cardiovascular protection, anti-aging and antioxidant effects. In conclusion, this paper summarizes in depth the shortcomings of the current research on Codonopsis Radix and proposes corresponding solutions. At the same time, this paper provides theoretical support for further research on the biological function and potential clinical efficacy of Codonopsis Radix.

Keywords: analysis method and quality control; codonopsis radix; ethnopharmacology; pharmacological effects; phytochemistry; processing methods.

Publication types

Review

Grants and funding

This work was financially supported by the National Natural Science Foundation of China (Grant Numbers 81960771); National Key Research and Development Program of China (2017YFC1703901, 2017YFC1703902).