C-reactive protein to lymphocyte ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 patients

Benjie Xiao; Yinyan Wu; Huazheng Liang; Jingjing Xiao; Yudi Han; Zhangwei Yang; Yong Bi

doi:10.3389/fpubh.2023.1168375

C-reactive protein to lymphocyte ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 patients

Front Public Health. 2023 Apr 6:11:1168375. doi: 10.3389/fpubh.2023.1168375. eCollection 2023.

Authors

Benjie Xiao¹, Yinyan Wu¹, Huazheng Liang^{2

3}, Jingjing Xiao¹, Yudi Han¹, Zhangwei Yang⁴, Yong Bi^{5

6}

Affiliations

¹ Department of Neurology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
² Clinical Research Center for Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
³ Monash Suzhou Research Institute, Suzhou, Jiangsu Province, China.
⁴ Department of Information, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
⁵ Shanghai University of Medicine & Health Sciences Affiliated Zhoupu hospital, Shanghai, China.
⁶ Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

Objective: The aim of the present study is to assess the utility of C-reactive protein to Lymphocyte Ratio (CLR) in predicting short-term clinical outcomes of patients infected by SARS-CoV-2 BA.2.2.

Methods: This retrospective study was performed on 1,219 patients with laboratory-confirmed SARS-CoV-2 BA.2.2 to determine the association of CLR with short-term clinical outcomes. Independent Chi square test, Rank sum test, and binary logistic regression analysis were performed to calculate mean differences and adjusted odds ratios (aORs) with their 95% CI, respectively.

Results: Over 8% of patients admitted due to SARS-CoV-2 BA.2.2. were critically ill. The best cut-off value of CLR was 21.25 in the ROC with a sensitivity of 72.3% and a specificity of 86%. After adjusting age, gender, and comorbidities, binary logistic regression analysis showed that elevated CLR was an independent risk factor for poor short-term clinical outcomes of COVID-19 patients.

Conclusion: C-reactive protein to Lymphocyte Ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 inflicted patients.

Keywords: C-reactive protein to lymphocyte ratio; SARS-CoV-2 BA.2.2; clinical outcomes; cut-off value; multivariate logistic regression.

MeSH terms

C-Reactive Protein / analysis
COVID-19*
Humans
Lymphocytes
ROC Curve
Retrospective Studies
SARS-CoV-2

Substances

C-Reactive Protein