Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts

Chunliang Zhang; Ruitao Cha; Chunyuan Wang; Xingming Chen; Zulan Li; Qian Xie; Liujun Jia; Yang Sun; Zhan Hu; Lin Zhang; Fengshan Zhou; Yan Zhang; Xingyu Jiang

doi:10.1016/j.biomaterials.2023.122124

Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts

Biomaterials. 2023 Jun:297:122124. doi: 10.1016/j.biomaterials.2023.122124. Epub 2023 Apr 11.

Authors

Chunliang Zhang¹, Ruitao Cha², Chunyuan Wang³, Xingming Chen⁴, Zulan Li⁴, Qian Xie⁵, Liujun Jia³, Yang Sun³, Zhan Hu³, Lin Zhang⁶, Fengshan Zhou⁷, Yan Zhang⁸, Xingyu Jiang⁹

Affiliations

¹ Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), No. 29 Xueyuan Road, Haidian District, Beijing, 100083, PR China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Haidian District, Beijing, 100190, PR China.
² CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Haidian District, Beijing, 100190, PR China. Electronic address: chart@nanoctr.cn.
³ Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, 100037, PR China.
⁴ PLA Strategic Support Force Characteristic Medical Center, No. 9 Anxiang Beili, Chaoyang District, Beijing, 100101, PR China.
⁵ Division of Nephrology, Peking University Third Hospital, No. 49 Huayuan Road North, Haidian District, Beijing, 100191, PR China.
⁶ Department of Adult Cardiac Surgery, Faculty of Cardiovascular Disease, The Sixth Medical Center of the General Hospital of the People's Liberation Army of China, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China. Electronic address: drzhanglin@outlook.com.
⁷ Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), No. 29 Xueyuan Road, Haidian District, Beijing, 100083, PR China. Electronic address: zhoufs@cugb.edu.cn.
⁸ Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng District, Beijing, 100037, PR China. Electronic address: waikezhangyan@126.com.
⁹ Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong, 518055, PR China. Electronic address: jiang@sustech.edu.cn.

PMID: 37087981
DOI: 10.1016/j.biomaterials.2023.122124

Abstract

The off-the-shelf small-diameter vascular grafts (SDVGs) have inferior clinical efficacy. Red blood cell membrane (Rm) has easy availability and multiple bioactive components (such as phospholipids, proteins, and glycoproteins), which can improve the clinic's availability and patency of SDVGs. Here we developed a facile approach to preparing an Rm-functionalized poly-ε-caprolactone/poly-d-lysine (Rm@PCL/PDL) tube by co-incubation and single-step rolling. The integrity, stability, and bioactivity of Rm on Rm@PCL/PDL were evaluated. The revascularization of Rm@PCL/PDL tubes was studied by implantation in the carotid artery of rabbits. Rm@PCL/PDL can be quickly prepared and showed excellent bioactivity with good hemocompatibility and great anti-inflammatory. Rm@PCL/PDL tubes as the substitute for the carotid artery of rabbits had good patency and quick remodeling within 21 days. Rm, as a "self" biomaterial with high biosafety, provides a new and facile approach to developing personalized or universal SDVGs for the clinic, which is of great significance in cardiovascular regenerative medicine and organ chip.

Keywords: Electrospinning; Personalized therapy; Poly-ε-caprolactone; Red blood cell membrane; Small-diameter vascular graft.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials
Blood Vessel Prosthesis
Cell Membrane
Nanofibers*
Polyesters
Rabbits
Tissue Scaffolds
Vascular Grafting*

Substances

Biocompatible Materials
Polyesters