Virus-host Interactions in Early Japanese Encephalitis Virus Infection

Yongzhe Zhu; Zhiwei He; Zhongtian Qi

doi:10.1016/j.virusres.2023.199120

Virus-host Interactions in Early Japanese Encephalitis Virus Infection

Virus Res. 2023 Jul 2:331:199120. doi: 10.1016/j.virusres.2023.199120. Epub 2023 May 1.

Authors

Yongzhe Zhu¹, Zhiwei He¹, Zhongtian Qi²

Affiliations

¹ Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.
² Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China. Electronic address: qizt@smmu.edu.cn.

Abstract

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic virus that can cause severe viral encephalitis. Initial interactions between JEV and host cells are required for productive viral infection and initiation of the viral life cycle. The elucidation of these interactions is critical, not only to understand the pathogenesis of JEV infection, but also to design efficient antiviral strategies. In this review, we outline the known viral and cellular components involved in JEV entry into host cells, with a particular focus on the initial virus-host cell interaction on the cell surface and the downstream early events such as endocytosis, membrane fusion, and viral genome release.

Keywords: Endocytosis mechanism; Japanese encephalitis virus; Membrane fusion; Putative receptor; Viral entry.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Encephalitis Virus, Japanese* / genetics
Encephalitis Viruses, Japanese*
Encephalitis, Japanese*
Endocytosis
Host Microbial Interactions
Humans
Virus Internalization
Virus Replication