A year in review: brain barriers and brain fluids research in 2022

Richard F Keep; Hazel C Jones; Mark G Hamilton; Lester R Drewes

doi:10.1186/s12987-023-00429-0

A year in review: brain barriers and brain fluids research in 2022

Fluids Barriers CNS. 2023 Apr 21;20(1):30. doi: 10.1186/s12987-023-00429-0.

Authors

Richard F Keep¹, Hazel C Jones², Mark G Hamilton³, Lester R Drewes⁴

Affiliations

¹ Department of Neurosurgery, University of Michigan, R5018 BSRB 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. rkeep@umich.edu.
² , Bicester, OX26 1UF, UK.
³ Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary, Alberta, Canada.
⁴ Department of Biomedical Sciences, University of Minnesota Medical School Duluth, Duluth, MN, 55812, USA.

Abstract

This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

Keywords: Blood-brain barrier; Brain endothelium; Cerebrospinal fluid, choroid plexus, drug delivery; Glymphatics, hydrocephalus, neurovascular unit.

Publication types

Editorial

MeSH terms

Blood-Brain Barrier*
Brain*
Cerebrospinal Fluid
Choroid Plexus