The bioavailability, solubility, stability, and evaporation rate of essential oils can all be improved by using appropriate nanocarriers. This study describes the simple biosynthesize, physicochemical, optical, and biological activity of Chitosan-Ferula gummosa essential oil (CS-FEO) nanocomposite. The prepared nanocomposite was evaluated by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) mapping, transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), UV-vis and photoluminescence (PL) techniques. The XRD investigation showed that crystallinity indexes of CS-FEO nanocomposite were lower than that of the pure CS and higher than nano-CS. According to SEM/TEM images, a spherical shape with a particle size distribution of around 50-250 nm for nanocomposite was obtained. PL measurement exhibited the addition of FEO caused a strong red emission. GC-MS analysis showed 40 various components in FEO. The antibacterial activity was studied using broth micro-dilution, disc diffusion, colony counts, and well agar diffusion methods against Gram-positive and Gram-negative bacteria. The results revealed that CS-FEO has stronger antibacterial activities than pure CS. It was also observed that the combined use of CS with FEO resulted in synergistic effects against studied bacteria. Obtained results imply that the CS-FEO may provide a new outlook in biomedical applications.
Keywords: Antibacterial activity; Essential oils; Nanocarriers; Nanoparticles.
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