Degrading the signal amplifier: ITK as a target for targeted protein degradation

Avery August

doi:10.1016/j.chembiol.2023.04.001

Degrading the signal amplifier: ITK as a target for targeted protein degradation

Cell Chem Biol. 2023 Apr 20;30(4):337-339. doi: 10.1016/j.chembiol.2023.04.001.

Author

Avery August¹

Affiliation

¹ Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA; Cornell Center for Immunology, Cornell University, Ithaca, NY 14853, USA; Cornell Institute of Host-Microbe Interactions and Defense, Cornell University, Ithaca, NY 14853, USA; Cornell Center for Health Equity, Cornell University, Ithaca, NY 14853, USA. Electronic address: averyaugust@cornell.edu.

PMID: 37084715
DOI: 10.1016/j.chembiol.2023.04.001

Abstract

In this issue of Cell Chemical Biology, Jiang and colleagues show for the first time that the Tec kinase ITK can be targeted using PROTAC approaches. This new modality has implications for the treatment of T cell lymphomas, but also potentially for the treatment of T cell-mediated inflammatory diseases, that depend on ITK signaling.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Proteolysis
Proteolysis Targeting Chimera* / metabolism
Signal Transduction*
T-Lymphocytes*

Substances

emt protein-tyrosine kinase
Proteolysis Targeting Chimera