NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Ilse Delint-Ramirez; Ram Madabhushi

doi:10.1016/j.molcel.2023.03.019

NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Mol Cell. 2023 Apr 20;83(8):1208-1209. doi: 10.1016/j.molcel.2023.03.019.

Authors

Ilse Delint-Ramirez¹, Ram Madabhushi²

Affiliations

¹ Departments of Psychiatry, Neuroscience, and Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Departments of Psychiatry, Neuroscience, and Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: ram.madabhushi@utsoutwestern.edu.

PMID: 37084713
DOI: 10.1016/j.molcel.2023.03.019

Abstract

In a recent study, Pollina et al.¹ discover a new neuron-specific NuA4-TIP60 chromatin remodeling complex that facilitates the repair of activity-induced DNA double-strand breaks (DSBs) in neurons and protects against mutations that accumulate with age and early death.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Basic Helix-Loop-Helix Transcription Factors*
DNA Breaks, Double-Stranded
DNA Repair*
Histone Acetyltransferases*
Histones* / metabolism
Transcription Factors / genetics
Transcription Factors / metabolism

Substances

Histones
Transcription Factors
Basic Helix-Loop-Helix Transcription Factors
Histone Acetyltransferases

Grants and funding

R01 MH120132/MH/NIMH NIH HHS/United States