Looping in on splicing: CRIC-seq uncovers PTBP1's long-range RNA regulatory rules

Ira Alexandra Iosub; Tajda Klobučar; Jernej Ule

doi:10.1016/j.molcel.2023.03.020

Looping in on splicing: CRIC-seq uncovers PTBP1's long-range RNA regulatory rules

Mol Cell. 2023 Apr 20;83(8):1206-1207. doi: 10.1016/j.molcel.2023.03.020.

Authors

Ira Alexandra Iosub¹, Tajda Klobučar², Jernej Ule³

Affiliations

¹ The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; UK Dementia Research Institute at King's College London, London, UK.
² National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia; Biosciences PhD Program, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
³ The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; UK Dementia Research Institute at King's College London, London, UK; National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia. Electronic address: jernej.ule@crick.ac.uk.

PMID: 37084712
DOI: 10.1016/j.molcel.2023.03.020

Abstract

RNA looping adds crucial information to understanding the position-dependent regulatory mechanisms of protein-RNA interactions. In this issue, Xue et al.¹ present CRIC-seq, which comprehensively identifies RNA loops mediated by specific proteins and demonstrates their value for interpreting disease-causing mutations.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alternative Splicing
Polypyrimidine Tract-Binding Protein* / genetics
Polypyrimidine Tract-Binding Protein* / metabolism
Proteins / genetics
RNA Splicing* / genetics
RNA*

Substances

Polypyrimidine Tract-Binding Protein
Proteins
RNA

Abstract

Publication types

MeSH terms

Substances

Grants and funding