Application of three dimensional-printed devices in extraction technologies

Abstract

Sample pretreatment is an important and necessary process in chemical analysis. Traditional sample preparation methods normally consume moderate to large quantities of solvents and reagents, are time- and labor-intensive and can be prone to error (since they usually involve multiple steps). In the past quarter century or so, modern sample preparation techniques have evolved, from the advent of solid-phase microextraction and liquid-phase microextraction to the present day where they are now widely applied to extract analytes from simple as well as complex matrices leveraging on their extremely low solvent consumption, high extraction efficiency, generally straightforward and simple operation and integration of most, if not all, of the following aspects: Sampling, cleanup, extraction, preconcentration and ready-to-inject status of the final extract. One of the most interesting features of the progress of microextraction techniques over the years lies in the development of devices, apparatus and tools to facilitate and improve their operations. This review explores the application of a recent material fabrication technology that has been receiving a lot of interest, that of three-dimensional (3D) printing, to the manipulation of microextraction. The review highlights the use of 3D-printed devices in the extraction of various analytes and in different methods to address, and improves upon some current extraction (and microextraction) problems, issues and concerns.

Keywords: Devices; Extraction; Microextraction; Three-dimensional printing.