Systematic identification of CRISPR off-target effects by CROss-seq

Affiliations

• ¹ MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
• ² Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
• ³ Institute for Biophysical Dynamics, Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.