Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin

Shilpi Goenka

doi:10.1016/j.bbadva.2022.100042

Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin

BBA Adv. 2022 Jan 17:2:100042. doi: 10.1016/j.bbadva.2022.100042. eCollection 2022.

Author

Shilpi Goenka¹

Affiliation

¹ Department of Biochemistry and Cellular Biology, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.

Abstract

Lipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E Coli and P gingivalis (LPS-PG) was examined in human melanocytes of lightly-pigmented (LP) and darkly-pigmented (DP) donors. Results showed no effect of any LPS on melanin production in both cells. B6 and B12 elicited higher levels of IL-6 than B5 in LP cells while B6 was more potent than B12 in DP cells. B5 and PG did not show any effect on IL-6 in both cells.

Keywords: Darkly-pigmented; E Coli; IL-6 cytokine; Lipopolysaccharide serotype; P. Gingivalis; lightly-pigmented.