Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

Yingying Lin; Zhiwei Chen; Qinfang Qian; Yanxia Wang; Xiaoyan Xiu; Ping Ou; Jiaoning Fang; Guobo Li

doi:10.3389/fendo.2023.1114250

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

Front Endocrinol (Lausanne). 2023 Mar 30:14:1114250. doi: 10.3389/fendo.2023.1114250. eCollection 2023.

Authors

Yingying Lin¹, Zhiwei Chen², Qinfang Qian³, Yanxia Wang³, Xiaoyan Xiu², Ping Ou¹, Jiaoning Fang², Guobo Li³

Affiliations

¹ Department of Healthcare, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
² Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
³ Department of Child Healthcare Centre, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

Abstract

Objective: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring.

Methods: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random sampling method from May to September 2019. They were divided into four groups based on paternal BMI. Univariate and multivariate logistic regression were used to explore the relationship between paternal BMI groups, maternal-neonatal outcomes, and long-term prognosis in offspring. Further subgroup analysis was conducted to examine the stability of the risk.

Results: The incidences of hypertensive disorder complicating pregnancy (HDCP), cesarean delivery, gestational weight gain (GWG) over guideline, and macrosomia were significantly higher in the paternal overweight and obesity group. Importantly, this study demonstrated that the incidence of asthma, hand-foot-and-mouth disease (HFMD), anemia, dental caries, and obesity of adolescents in paternal obesity increased. Furthermore, logistic regression and subgroup analysis confirm paternal obesity is a risk factor for HDCP, cesarean delivery, and macrosomia. It caused poor long-term prognosis in adolescents, including asthma, dental caries, and HFMD.

Conclusions: Paternal obesity is a risk factor for adverse maternal-neonatal outcomes and poor long-term prognosis in adolescents. In addition to focusing on maternal weight, expectant fathers should pay more attention to weight management since BMI is a modifiable risk factor. Preventing paternal obesity can lead to better maternal and child outcomes. It would provide new opportunities for chronic diseases.

Keywords: BMI; long-term; maternal-neonatal outcomes; paternal obesity; prognosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Body Mass Index
Child
Dental Caries
Fathers*
Female
Fetal Macrosomia / etiology
Humans
Infant, Newborn
Male
Obesity* / complications
Obesity* / diagnosis
Obesity* / epidemiology
Pregnancy
Pregnancy Complications / etiology
Pregnancy Outcome
Prognosis
Risk Factors
Weight Gain

Grants and funding

Joint Funds for the innovation of science and Technology, Fujian province (Grant number: 2020Y9165).Joint Funds for the invention of science and Technology, Fujian province (Grant number: 2020Y9147). Fujian Natural Science Foundation, Project(Grant number: 2020J01335).