NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death

Han Xu; Huaping Deng; Xiaoqian Ma; Yushuo Feng; Ruizhen Jia; Yiru Wang; Yaqing Liu; Wenli Li; Shanshan Meng; Hongmin Chen

doi:10.1186/s12951-023-01882-7

NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death

J Nanobiotechnology. 2023 Apr 20;21(1):132. doi: 10.1186/s12951-023-01882-7.

Authors

Han Xu¹, Huaping Deng¹, Xiaoqian Ma¹, Yushuo Feng¹, Ruizhen Jia¹, Yiru Wang¹, Yaqing Liu¹, Wenli Li¹, Shanshan Meng¹, Hongmin Chen^{2

3}

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular, Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
² State Key Laboratory of Molecular Vaccinology and Molecular, Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China. hchen@xmu.edu.cn.
³ State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts & Telecommunications, Nanjing, 210023, People's Republic of China. hchen@xmu.edu.cn.

Abstract

Photothermal therapy has shown great promise for cancer treatment and second near-infrared (NIR-II) -absorbing particles could further improve its precision and applicability due to its superior penetration depth and new imaging ability. Herein, high NIR-II-absorbing polymer particles were prepared by using soluble isobutyl-substituted diammonium borates (P-IDI). The P-IDI showed stronger absorption at 1000-1100 nm, which exhibited excellent photostability, strong photoacoustic imaging ability and high photothermal conversion efficiency (34.7%). The investigations in vitro and in vivo demonstrated that the excellent photothermal effect facilitated complete tumor ablation and also triggered immunogenic cell death in activation of the immune response. The high solubility and excellent photothermal conversion ability demonstrated that polymer IDI particles were promising theranostic agents for treatment of tumors with minor side effects.

Keywords: Diimmonium salt; NIR-II absorbing organic agent; Photothermal therapy; Tumor immunogenic cell death.

MeSH terms

Cell Line, Tumor
Humans
Immunogenic Cell Death
Nanoparticles*
Neoplasms* / drug therapy
Photoacoustic Techniques* / methods
Phototherapy / methods
Photothermal Therapy
Polymers

Substances

Polymers