Non-driver mutations landscape in different stages of primary myelofibrosis determined ASXL1 mutations play a critical role in disease progression

Xin Yan; Zefeng Xu; Peihong Zhang; Qi Sun; Yujiao Jia; Tiejun Qin; Shiqiang Qu; Lijuan Pan; Zhanqi Li; Jinqin Liu; Zhen Song; Qingyan Gao; Meng Jiao; Jingye Gong; Huijun Wang; Bing Li; Zhijian Xiao

doi:10.1038/s41408-023-00829-3

Non-driver mutations landscape in different stages of primary myelofibrosis determined ASXL1 mutations play a critical role in disease progression

Blood Cancer J. 2023 Apr 20;13(1):56. doi: 10.1038/s41408-023-00829-3.

Authors

Xin Yan^{1

2}, Zefeng Xu^{1

2

3}, Peihong Zhang⁴, Qi Sun⁴, Yujiao Jia⁴, Tiejun Qin³, Shiqiang Qu^{1

2

3}, Lijuan Pan³, Zhanqi Li⁴, Jinqin Liu^{1

2}, Zhen Song⁵, Qingyan Gao³, Meng Jiao³, Jingye Gong^{1

2}, Huijun Wang⁴, Bing Li^{6

7

8}, Zhijian Xiao^{9

10

11

12}

Affiliations

¹ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
² Tianjin Institutes of Health Science, Tianjin, 301600, China.
³ MDS and MPN Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
⁴ Hematologic Pathology Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
⁵ Centre for Information and Resources, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
⁶ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. libing@ihcams.ac.cn.
⁷ Tianjin Institutes of Health Science, Tianjin, 301600, China. libing@ihcams.ac.cn.
⁸ MDS and MPN Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. libing@ihcams.ac.cn.
⁹ State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. zjxiao@ihcams.ac.cn.
¹⁰ Tianjin Institutes of Health Science, Tianjin, 301600, China. zjxiao@ihcams.ac.cn.
¹¹ MDS and MPN Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. zjxiao@ihcams.ac.cn.
¹² Hematologic Pathology Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. zjxiao@ihcams.ac.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Disease Progression
Humans
Mutation
Primary Myelofibrosis* / genetics
Repressor Proteins / genetics

Substances

Repressor Proteins
ASXL1 protein, human