Efficacy of exercise training for improving vascular dysfunction in people with cancer: a systematic review with meta-analyses

Natalie K Vear; Yubin Moon; Gregore I Mielke; Tina L Skinner; Jeff S Coombes; Alexandra L McCarthy; Claudia R Abbott; Tom G Bailey

doi:10.1007/s11764-023-01372-7

Efficacy of exercise training for improving vascular dysfunction in people with cancer: a systematic review with meta-analyses

J Cancer Surviv. 2023 Apr 20. doi: 10.1007/s11764-023-01372-7. Online ahead of print.

Authors

Natalie K Vear^{1

2

3}, Yubin Moon⁴, Gregore I Mielke⁵, Tina L Skinner⁶, Jeff S Coombes^{7

6}, Alexandra L McCarthy^{4

8}, Claudia R Abbott⁴, Tom G Bailey^{4

7

6}

Affiliations

¹ School of Nursing, Midwifery and Social Work, The University of Queensland, Level 3, Chamberlain Building (35), St Lucia, Queensland, 4072, Australia. n.vear@uq.edu.au.
² Physiology and Ultrasound Laboratory in Science and Exercise, School of Human Movement and Nutrition Sciences, The University of Queensland, Level 2, Connell Building (26), St Lucia, Queensland, 4072, Australia. n.vear@uq.edu.au.
³ Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Level 2, Connell Building (26), St Lucia, Queensland, 4072, Australia. n.vear@uq.edu.au.
⁴ School of Nursing, Midwifery and Social Work, The University of Queensland, Level 3, Chamberlain Building (35), St Lucia, Queensland, 4072, Australia.
⁵ School of Public Health, The University of Queensland, Herston, Queensland, 4006, Australia.
⁶ Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Level 2, Connell Building (26), St Lucia, Queensland, 4072, Australia.
⁷ Physiology and Ultrasound Laboratory in Science and Exercise, School of Human Movement and Nutrition Sciences, The University of Queensland, Level 2, Connell Building (26), St Lucia, Queensland, 4072, Australia.
⁸ Mater Research Institute, Level 3, Aubigny Place, Raymond Terrace, South Brisbane, Queensland, 4101, Australia.

PMID: 37079184
DOI: 10.1007/s11764-023-01372-7

Abstract

Purpose: Cancer treatments exert vascular toxic effects that can lead to the development of cardiovascular disease. Exercise training has the potential to prevent or reduce cancer treatment-induced damage to vascular structure and function. This systematic review with meta-analyses aimed to determine the isolated effects of exercise training on vascular outcomes in people with cancer.

Methods: Seven electronic databases were searched on 20 September 2021 to identify randomised controlled trials, quasi-randomised trials, pilot and cohort studies. Included studies implemented a structured exercise intervention and assessed vascular structure and/or function in people during or following cancer treatment. Meta-analyses examined the effects of exercise training on endothelial function (via brachial artery flow-mediated dilation) and arterial stiffness (via pulse wave velocity). Methodological quality was assessed using the Cochrane Quality Assessment tool and modified Newcastle-Ottawa Quality Appraisal tool. Grading of Recommendations, Assessment, Development and Evaluations framework was used to assess the certainty of evidence.

Results: Ten studies (discussed across 11 articles) met the inclusion criteria. Methodological quality of the included studies was moderate (71% average). Exercise improved vascular function when compared to control (standardised mean difference = 0.34, 95% CI (0.01, 0.67); p = 0.044: studies = 5, participants = 171), but not pulse wave velocity (standardised mean difference = - 0.64, 95% CI (- 1.29, 0.02); p = 0.056: studies = 4, participants = 333). The certainty of evidence was moderate for flow-mediated dilation and low for pulse wave velocity.

Conclusions: Compared to usual care, exercise training significantly improves flow-mediated dilation (endothelial function) but not pulse wave analysis, in people treated for cancer.

Implications for cancer survivors: Exercise may improve vascular health in individuals during and following cancer treatment.

Keywords: Cardiotoxicity; Carotid intima-media thickness; Exercise physiology; Neoplasms; Physical activity; Pulse wave analysis.

Publication types

Review