1 Department of Ophthalmology (MR, JO, JM, FF-R, JB-B), Centro Hospitalar e Universitário de São João, Porto, Portugal; Department of Biomedicine (MR), Unit of Pharmacology and Therapeutics, Faculty of Medicine of Porto University, Porto, Portugal; Department of Neurology (RS-d-R), Centro Hospitalar e Universitário de São João, Porto, Portugal; Department of Clinical Neurosciences and Mental Health (RS-d-R), Faculty of Medicine, University of Porto, Porto, Portugal; Department of Neuroradiology (MLS, LA), Centro Hospitalar e Universitário de São João, Porto, Portugal; Department of Surgery and Physiology (FF-R), Faculty of Medicine of Porto University, Porto, Portugal; UnIC@RISE (JB-B), Department of Surgery and Physiology, Faculty of Medicine of Porto University, Porto, Portugal; and KU Leuven (JB-B), Research Group Ophthalmology, Department of Neurosciences, Leuven, Belgium.