In vitro comparative study of multimodal imaging nano-assembled microspheres with two clinical drug-eluting beads loaded with doxorubicin

Yiwei He; Tiancheng Xu; Tingting Ding; Yuanchuan Gong; Hui Zeng; Zihan Xi; Yuanxin Ye; Ziyang Song; Ting Pan; Zhewei Zhang; Qian Ma; Lihua Li; Yuqing Zhang; Guoliang Shao

doi:10.1080/10717544.2023.2197177

In vitro comparative study of multimodal imaging nano-assembled microspheres with two clinical drug-eluting beads loaded with doxorubicin

Drug Deliv. 2023 Dec;30(1):2197177. doi: 10.1080/10717544.2023.2197177.

Authors

Yiwei He^{1

2}, Tiancheng Xu³, Tingting Ding³, Yuanchuan Gong¹, Hui Zeng¹, Zihan Xi¹, Yuanxin Ye^{1

2}, Ziyang Song^{1

2}, Ting Pan¹, Zhewei Zhang¹, Qian Ma¹, Lihua Li³, Yuqing Zhang³, Guoliang Shao^{1

2}

Affiliations

¹ Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
² Second Clinical Medical College of Zhejiang, Chinese Medical University, Hangzhou, China.
³ School of Automation, Hangzhou Dianzi University, Hangzhou, China.

Abstract

DC Beads and CalliSpheres are commonly used microspheres in clinical transcatheter arterial chemoembolization, but these microspheres cannot be visualized by themselves. Therefore, in our previous study, we developed multimodal imaging nano-assembled microspheres (NAMs), which are visualized under CT/MR and the location of embolic microspheres can be determined during postoperative review, facilitating the evaluation of embolic areas and guiding subsequent treatment. Moreover, the NAMs can be carried with positively and negatively charged drugs, increasing the choice of drugs. Systematic comparative analysis of the pharmacokinetics of NAMs with commercially available DC Bead and CalliSpheres microspheres is important for evaluating the clinical application of NAMs. In our study, we compared the similarities and differences between NAMs and two drug-eluting beads (DEBs) in respect to drug loading capacity, drug release profiles, diameter variation and morphological characteristics. The results indicate that NAMs had good drug delivery and release characteristics as well as DC Bead and CalliSpheres in vitro experimental stage. Therefore, NAMs have a good application prospect in transcatheter arterial chemoembolization treatment of hepatocellular carcinoma.

Keywords: Comparative study; doxorubicin; drug loading; drug release; drug-eluting beads.

MeSH terms

Antibiotics, Antineoplastic
Carcinoma, Hepatocellular* / drug therapy
Chemoembolization, Therapeutic* / methods
Doxorubicin
Humans
Liver Neoplasms* / drug therapy
Microspheres

Substances

Antibiotics, Antineoplastic
Doxorubicin

Grants and funding

This research was funded by the National Natural Science Foundation of China (Nos. 82072032 and 61905057), Zhejiang Provincial Natural Science Foundation of China (LY21A040002) and Medical Science and Technology Project of Zhejiang Province (2021427572).